×100. ×100. The mesenteric, mediastinal and paralumbar lymph nodes are often affected (Frith et al 2000b). Eosinophilic crystals in the rat lung. FIGURE 2.7b Age-related vascular medial cartilage and mineralization in the tongue of a rat. How do I calculate cell viability in MTT assay? Pulp stones often form around cellular debris (Bertram et al 1996). 2.32) are generally found in the bronchiolar epithelium. Vascular mineralization in arteries and veins in various organs such as the lung, is occasionally observed as a background lesion in rats. The rat is the most commonly used rodent species for toxicology studies. In 1991, 8 colonies were selected to form the IGS Foundation Colony. 2.9) of various different lymph nodes (also known as sinus dilatation, lymphangiectasia, cystic ectasia, lymphatic sinus ectasia, lymphangiectasis, lymphatic cysts) is observed as a background lesion in rat lymph nodes. Arteritis (polyarteritis, periarteritis, panarteritis nodosa) (Fig. Recently spontaneous short-tailed rats appeared in a random-breeding colony of the Long-Evans stock. FIGURE 2.39 Mineralization of mucus within a bronchiole in the rat lung. Medial degeneration is common in the coronary arteries of rats and the affected vessels display enlarged, irregularly arranged and sparse nuclei present in a PAS-positive matrix (Ruben 2000). Hair shaft emboli or skin fragment emboli are seen in the lungs of animals on intravenous injection studies. ×200. FIGURE 2.12 Russell bodies in a lymph node. Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley … Animal Diet: NIH #31M Rodent Diet. FIGURE 2.24 Mural mineralization of an artery in the rat lung. FIGURE 2.19 Thymus hemorrhage and eosinophlilic crystals. Thymic cysts (. The rat is the most commonly used rodent species for toxicology studies. The rat spleen, particularly in female animals, normally has minimal to slight amounts of hemosiderin. 2.24). Arteritis (polyarteritis, periarteritis, panarteritis nodosa) (Fig. ×100. ×200. Age-related vascular medial cartilage and mineralization may be encountered in the blood vessels of aging rats (Fig. Thymic cysts are often lined by squamous cells or ciliated epithelium. P rats were double-housed until growing to 325–350 g, and from this weight all animals were single-housed, in filter-ventilated cages (Thoren Caging System, Inc., Hazleton, PA) at 22 ± 1.5° C and 42 ± 8% humidity … The etiology of this finding is unknown. This lesion is common and generally occurs due to the presence of hemorrhage in the organs draining into the lymph nodes. 2.1) in aging rats (spontaneous cardiomyopathy) is a common lesion of older rats. FIGURE 2.8 Macrophages with brown pigment in the mesenteric lymph node. The lesion is not associated with metastatic calcification. The cysts are lined by endothelial cells and contain a pink proteinaceous fluid (Stefanski et al 1990). A strain, in reference to rodents, is a group in which all members are, as nearly as possible, genetically identical. Although the thymus continues to increase in size initially, it begins to regress and at the end of a carcinogenicity study of two year duration the thymus will be severely depleted (Stefanski et al 1990). Histologically, Fordyce’s granules are identical to their cutaneous counterpart but are not associated with hair follicles. Ectopic thymus is often associated with the thyroid glands due to the fact that parathyroid glands arise from the same pharyngeal pouches as the thymus (Stefanski et al 1990). ×100. What is the best software for making and editing scientific images for publication quality figures? It is characterized by its wide head, long ears, and a tail length that is always less than its body length. CD® (Sprague Dawley) IGS Rat Details. Atherosclerosis is a rare background lesion consisting of focal areas of foam cells within the tunica intima or tunica media (Ruben 2000). The pathology of the aged rat becomes important in the latter stages of carcinogenicity studies (Chandra & Frith 1992). FIGURE 2.4 Cartilage at base of aorta in a rat. 2.31) is a common aging change in rats and is observed in most two-year-old rats on carcinogenicity studies. It has a high reproductive rate and low incidence of spontaneous tumors. At that time, the behavior of each naive rat was observed for two 3-minute periods separated by an interval of 24 h (Day). The lesion is characterized initially by necrotic, eosinophilic cardiomyocytes surrounded by fibroblasts and inflammatory cells (Fig. This chapter will give an overview of background lesions encountered in both young and older Wistar and Sprague-Dawley rats. ×200. ×100. Mural mineralization of an artery in the rat lung. Initially a virus was suggested as the cause (rat respiratory virus) (Albers et al 2009), but recently researchers have demonstrated a correlation between the presence of inflammatory lung lesions and Pneumocystis carinii DNA detected by PCR (Livingston et al 2011). Mineralization of mucus within a bronchiole in the rat lung. Furthermore, mineralization of mucus is rarely noted within bronchioles of the lungs and within the lumena of the nasal turbinates (Figs 2.39, 2.40). 2.12). FIGURE 2.37 Osseus metaplasia in the rat lung. A rat strain is created through breeding to produce rats that are similar to each other and … Tatto pigment in a rat popliteal lymph node. Reproduction of the rat, mouse, dog, non-human primate and minipig, Non-human primates: Cynomolgus (Macaca fascicularis) and rhesus (Macaca mulatta) macaques and the common marmoset (Callithrix jacchus), Background Lesions in Laboratory Animals A Color Atlas. 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